Searchable abstracts of presentations at key conferences in endocrinology

ea0094p316 | Adrenal and Cardiovascular | SFEBES2023

Deciphering atherosclerosis: unravelling spatial lipid heterogeneity through advanced MALDI-MSI profiling in rabbit aortic and human carotid artery plaques

Ntshangase Sphamandla , Khan Shazia , Gazarkova Taťana , Bezuidenhout Louise , Kaczynski Jakub , Sellers Stephanie , Newby David , Hadoke Patrick , Andrew Ruth

Atherosclerosis, a multifaceted cardiovascular disease characterised by fatty plaque buildup in large and medium-sized arteries, is a leading cause of heart attacks, strokes and peripheral arterial disease. Its global impact on morbidity and mortality rates poses a significant health challenge. This study aimed to comprehensively understand its complex pathogenesis using histologically aided Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry Imaging (MALDI-MSI) to e...